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SOAP STATEMENT ON ACETAMINOPHEN IN PREGNANCY The Society for Obstetric Anesthesia and Perinatology (SOAP) affirms the importance of protecting maternal and fetal health through safe, effective, and evidence-informed approaches to pain and fever management in pregnancy. As experts in pregnancy and postpartum pain care, anesthesiologists play a central role in ensuring that safe, effective, and evidence-based options are available to pregnant patients. Acetaminophen is one of the most used medications in pregnancy, with a long history of safety when taken as recommended. Current evidence does not support a causal relationship between acetaminophen use in pregnancy and adverse neurodevelopmental outcomes. In contrast, untreated maternal fever and pain are well-documented threats to maternal and fetal health with associated with adverse outcomes. Clinical decision-making should continue to prioritize shared discussions between patients and their healthcare providers. SOAP has a responsibility to guide families with clarity, balance, and compassion, ensuring that decisions are grounded in the best available science. In alignment with the American College of Obstetricians and Gynecologists (ACOG) and the Society for Maternal-Fetal Medicine (SMFM), SOAP joins our obstetric colleagues in affirming that acetaminophen remains an appropriate and essential option for pregnant patients. Together, we stand in advocating for safe, evidence-based maternal care and for the best outcomes for mothers and babies.
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